Newer Neuromuscular Blocking Agents

Neuromuscular Blocking Agents

• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...

Neuromuscular blocking agents: a review.

The author provides a review of the mechanism of neuromuscular transnission, as well as the Nechanisn of action and differences between curare and succinylcholine. Effects of these two relaxants on various organs and tissues are discussed, as are their onset of action, duration, elimination, and clinical uses. In order to understand how skeletal muscle re-laxants act, the mechanism of neuromusc...

Indications for Neuromuscular Blocking Agents

©International Anesthesia Research Society. Unauthorized Use Prohibited. Almost thirty years ago, residual neuromuscular blockade was documented in a surprisingly high proportion of patients (30%), despite an almost systematic use of anticholinesterase agents.1 Since then, even with the development of shorter-acting neuromuscular blockers, pharmacological reversal, and more widespread use of ne...

Newer Neuromuscular Blocking Drugs - Whether to Reverse or Not?

An editorial by Churchill-Davidson in 1965 expressed the clinical problem succinctly: ‘To reverse, or not to reverse’: that is the question! Since the introduction of d-tubocurarine into clinical anaesthesia this question has received opposing answers’. Now, more than six decades later this issue has yet to be resolved. The introduction of neuromuscular blocking drugs (NMBD) into anaesthetic pr...

tracheal intubation without the use of neuromuscular blocking agents